![]() Separation was performed with reversed-phase liquid chromatography followed by detection with positive electrospray-triple quadrupole mass spectrometry in the selected reaction monitoring mode. Salting-out assisted liquid-liquid extraction (SALLE), using acetonitrile and magnesium sulfate, was selected as sample pretreatment with deuterated quizartinib as internal standard. Electronic address: bioanalytical assay for quizartinib -a potent, and selective FLT3 tyrosine kinase inhibitor- in mouse plasma was developed and validated. Electronic address: 6 Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, UniversiteitsCG Utrecht, The Netherlands Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Chemical Biology & Drug Development, UniversiteitsCG Utrecht, The Netherlands. ![]() Electronic address: 5 Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, UniversiteitsCG Utrecht, The Netherlands The Netherlands Cancer Institute, Department of Clinical Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands MC Slotervaart, Department of Pharmacy & Pharmacology, LouwesEC Amsterdam, The Netherlands. Electronic address: 4 Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, UniversiteitsCG Utrecht, The Netherlands The Netherlands Cancer Institute, Department of Clinical Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address: 3 The Netherlands Cancer Institute, Department of Molecular Oncology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address: 2 The Netherlands Cancer Institute, Department of Molecular Oncology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. 1 Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, UniversiteitsCG Utrecht, The Netherlands. ![]()
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